Butabarbital is a drug used in the treatment of severe insomnia. This medicine is not intended for long-term use. In addition, this drug can also be used as a sedative before surgery.

Butabarbital is included in the barbiturate group of drugs . This drug works by disrupting the transmission of signals in the brain. That way, the work of the central nervous system will slow down. This drug can also relieve anxiety and has a calming effect, so it is often used before surgery.

Trademarks of butabarbital:  -

What Is Butabarbital?

Group Prescription drugs
Category Barbiturate sedatives
Benefits Dealing with insomnia and as a sedative before surgery
Consumed by Adults and children
Butabarbital for pregnant and lactating women Category N: Not yet categorized. From several studies, barbiturate drugs are believed to have a relationship with an increased risk of congenital abnormalities in the fetus.

Butabarbital content can be absorbed into breast milk. If you are breastfeeding, do not consume this medicine before consulting your doctor.

Drug form Tablets or syrup

Warnings Before Consuming Butabarbital

Butabarbital is a drug that must be consumed according to a doctor's prescription. Consider the following before consuming butabarbital:

  • Do not use butabarbital if you are allergic to this drug or tartrazine.
  • Tell your doctor if you suffer from porphyria , severe respiratory disease, or liver disease . Butabarbital should not be used by patients with these conditions.
  • Do not do activities that require alertness, including driving a vehicle after consuming butabarbital, because this drug can cause drowsiness .
  • Tell the doctor if you have ever or are currently experiencing alcohol addiction , NAPZA abuse, angioedema , mental disorders, such as depression .
  • Tell your doctor that you are taking butabarbital if you plan to undergo certain laboratory tests or surgery.
  • Tell your doctor if you are taking certain medications, supplements, or herbal products.
  • Tell your doctor if you are pregnant, breastfeeding, or planning to become pregnant.
  • Do not use butabarbital for more than 2 weeks without a doctor's advice. Follow the control schedule given by the doctor during treatment with butabarbital, so that your condition can be monitored.
  • Do not consume alcoholic beverages  during treatment with butabarbital, as it can increase the risk of side effects
  • Immediately see a doctor if you experience a drug allergic reaction , overdose, or more serious side effects.

Dosage and Administration of Butabarbital

The dose of butabarbital will be determined by the doctor according to the purpose, the patient's condition, and age. In general, the following are the details of the dose of butabarbital according to the purpose of use:

Purpose:  Help the treatment of insomnia

  • Adults: 50–100 mg, once daily, at night.

Purpose:  As a sedative before surgery

  • Adults: 50–100 mg, 60–90 minutes before surgery.
  • Children: 2–6 mg/kgBW, not more than 100 mg, 60–90 minutes before surgery.

How to Consume Butabarbital Correctly

Consume butabarbital as recommended by the doctor  and read the instructions for use found on the medicine packaging. Do not reduce or increase the dose of butabarbital consumed because it can increase the risk of you experiencing side effects or drug addiction.

Butabarbital is usually consumed on an empty stomach. Swallow butabarbital tablets with a glass of water. Meanwhile, use the measuring tool available if you need to consume butabarbital in the form of syrup, so that the amount of medicine consumed is accurate.

To treat insomnia, this drug is only used as a temporary therapy. It is recommended that you continue to practice sleep hygiene  to help overcome the sleep disorders you experience. Contact a doctor if the symptoms of insomnia do not improve or worsen after taking the medicine for 7-10 days in a row.

Do not stop using butabarbital suddenly because it can cause side effects or withdrawal symptoms that can be characterized by symptoms such as anxiety, muscle twitching, difficulty sleeping, or uncontrollably shaking fingers and hands. Follow the control schedule given by the doctor, so that your condition can be monitored.

Store butabarbital in a closed container in a cool, dry place away from direct sunlight. Keep this medicine out of the reach of children.

Interactions of Butabarbital with Other Drugs

There are several drug interaction effects that can arise when butabarbital is used with certain drugs, among others:

  • Decreased levels of doravirine, fostemsavir, lonafanib, lorlatinib, or warfarin in the blood
  • Decreased effectiveness of hormonal contraceptives, such as birth control pills
  • Increased effect of butabarbital if used with calcium oxybate, magnesium oxybate, or sodium oxybate
  • Increased risk of liver damage if used with paracetamol
  • Increased risk of fatal side effects, including severe respiratory distress, coma, and even death, if used with opioid drugs, such as buprenorphine or codeine

Side Effects and Dangers of Butabarbital

There are several side effects that can arise after consuming butabarbital that can occur, namely:

  • Drowsy
  • Worsening insomnia
  • Nightmare
  • Dizziness or headache
  • Constipation  or diarrhea
  • Confused, nervous, or irritable
  • Nausea or vomiting

Check with your doctor if the above side effects do not improve or get worse. See a doctor immediately if an allergic reaction to the drug or a more serious side effect occurs, such as:

  • Sleep walking
  • Breathing becomes slow
  • Slow heart rate
  • Edema or swelling in the legs and arms
  • Depression
  • Hallucinations
  • Low blood pressure ( hypotension )
  • Easy to bruise
  • Jaundice
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