Butorphanol is used to treat moderate to severe pain, such as muscle pain, migraine headaches, or pain from surgery. This drug can also be used as an anesthetic before and during surgery, as well as to relieve pain during labor.

Butorphanol is an opioid class of pain relievers. This drug works by inhibiting pain stimuli that go to the brain and reducing the pain response in the brain, so that the body does not feel pain.

Although it has many benefits, butorphanol can cause dependence if used for a long time. Therefore, the use of this drug must be in accordance with the doctor's recommendations.

Trademarks of butorphanol: -

What is Butorphanol

class Prescription drug
Category Opioid pain relievers
Benefit Relieves moderate to severe pain, as an anesthetic (anesthesia) during surgery, and relieves pain during labor
Used by Adults and seniors

Butorphanol for pregnant and lactating women

Category C: Animal studies have shown an adverse effect on the fetus, but there have been no controlled studies in pregnant women.

Drugs should only be used if the expected benefit outweighs the risk to the fetus.

Butorphanol can be absorbed into breast milk. If you are breastfeeding, do not use this medication without consulting your doctor.

Drug form Injections and nasal sprays

Warning Before Using Butorphanol

Butorphanol should not be used carelessly and must be according to a doctor's prescription. Here are some things you need to pay attention to before using butorphanol:

  • Do not use butorphanol if you are allergic to this drug. Be sure to always tell your doctor about any allergies you have.
  • Do not drive a vehicle or operate tools that require alertness while taking butorphanol, because this drug can cause dizziness and drowsiness.
  • Tell your doctor if you have severe asthma or other breathing problems, such as Chronic Obstructive Pulmonary Disease ( COPD ), or if you have symptoms of intestinal obstruction , such as abdominal pain, enlarged abdomen, unable to pass stools or gas, swollen abdomen, and nausea vomiting.
  • Tell your doctor if you have or are currently addicted to alcohol or other illegal drugs , or are using opioid pain relievers for a long time.
  • Tell your doctor if you have or currently have liver disease, gallbladder disorders, pancreatitis , kidney disease, heart disease, hypertension, Addison 's disease , kyphoscoliosis, enlarged prostate, hypothyroidism , head injury, brain tumor, seizures, psychosis , or sleep apnea .
  • Tell your doctor if you are pregnant, breastfeeding or planning a pregnancy.
  • Tell your doctor if you are taking any other medicines, including supplements or herbal products.
  • Be careful using butorphanol in the elderly because the risk of side effects is greater.
  • Tell your doctor that you are having treatment with butorphanol before having surgery or any medical procedure, including dental surgery.
  • See your doctor right away if you have an allergic reaction , serious side effects, or overdose after using butorphanol.

Dosage and Rules for Use Butorphanol

The dose of butorphanol is determined based on the age, condition of the patient and the body's response to the drug. Butorphanol can be given as a nasal spray or injection. The following is the dosage of butorphanol based on the form of the drug:

Form of Nasal Spray

Condition: Moderate to severe pain for migraines , muscle pain, or pain after surgery

  • Adult: 1–2 mg (1 spray in 1 nostril) on pain, may repeat after 3–4 hours if needed.
  • Elderly: Initially 1 mg, may repeat after 90–120 minutes. Subsequent doses may be given at 6-hour intervals if needed.

Injection Form

Condition: Moderate to severe pain

  • Adult: 1–4 mg, may repeat in 3–4 hours if needed.

Conditions: As an anesthetic before or during surgery

  • Adult: 2 mg before surgery and 0.5–1 during surgery.

Condition: Pain during labour

  • Adult: 1–2 mg at onset of labor, may repeat after 4 hours if needed.

How to Use Butorphanol Properly

Follow the doctor's recommendations and read the information listed on the drug packaging before using butorphanol. Do not add or reduce the dose without consulting a doctor, and do not use the drug for more than the recommended time.

Injectable butorphanol should only be given by a doctor or medical officer under the supervision of a doctor. The doctor will inject butorphanol according to the patient's condition.

If you are using butorphanol as a nasal spray , clean your nose and shake the bottle before using it. Position your head slightly back. Close one nostril with your finger, then squirt the medication into the nostril on the other side.

If you still have pain after 60–90 minutes, your doctor may recommend that you apply a second spray into the nostril that was not sprayed.

After using butorphanol nasal spray , it is recommended that you lie down for a while to anticipate the effects, such as dizziness. Make sure there is sufficient time between one dose and the next (3–4 hours).

Keep butorphanol nasal spray in the package. Place the medicine in a cool and dry room. Avoid exposure to direct sunlight and keep out of reach of children.

Interactions of Butorphanol with Other Drugs

Interaction effects that can occur if butorphanol is used with certain drugs include:

  • Increased effect of butorphanol when used with phenothiazines , antihistamines, benzodiazepines , or barbiturate drugs
  • Increased risk of fatal side effects when used with monoamine oxidase inhibitor ( MAOI ) class drugs
  • Increased risk of developing hypertension if used with sumatriptan nasal spray form
  • Increased risk of eye irritation when used with pancuronium
  • Decreased butorphanol levels when used with oxymetazoline in the form of a nasal spray

Butorphanol Side Effects and Dangers

Side effects that may arise after using butorphanol are:

  • Nauseous
  • Vomit
  • Sleepy
  • Dizziness or headache
  • Dry mouth
  • The skin feels warm and red
  • Blurred vision
  • Constipation
  • Nose irritation
  • Hard to sleep
  • sweat more

Check with your doctor if the above complaints don't go away or get worse. See your doctor immediately if you experience an allergic reaction or more serious side effects, such as:

  • Worry
  • Hallucinations
  • Shortness of breath or breathing becomes heavy
  • Fast or irregular heartbeat ( arrhythmia )
  • Severe stomach ache
  • Difficulty urinating
  • No appetite
  • Fatigue
  • Dizzy to the point of fainting
  • seizures
Back to blog