Ceftriaxone is a drug to treat diseases caused by bacterial infections , such as gonorrhea, meningitis , otitis media, syphilis, and Lyme disease. This drug is available in injectable form.
Cefriaxone is a cephalosporin class of antibiotics. This drug works by killing and inhibiting the growth of infection-causing bacteria in the body. In addition, ceftriaxone can also be used to prevent infection during surgery.
Please note, ceftriaxone cannot be used to treat infections caused by viruses, such as the flu .
Cefriaxone trademarks : Betrix, Broadced, Ceftriaxone Sodium, Cefaxon, Ceftrimet, Cetriax, Erphacef, Foricef, Futaxon, Gracef, Intrix, Racef, Renxon, Triasco, Trijec, Tricefin, Trixon, Tyason, and Zeftrix.
What is Ceftriaxone
|Benefit||Treat and prevent bacterial infections|
|Used by||Adults and children|
|Ceftriaxone for pregnant and lactating women||
Category B: Animal studies have not demonstrated a risk to the fetus, but there are no controlled studies in pregnant women.
Cefriaxone can be absorbed into breast milk. If you are breastfeeding, do not use this medicine without consulting your doctor first.
Warning Before Using Cefriaxone
Ceftriaxone should only be used according to a doctor's prescription. This medicine should not be used in premature babies, babies less than 1 month old, or babies with jaundice . Other things that need to be considered before using this drug, namely:
- Tell your doctor if you are allergic to ceftriaxone or any other cephalosporin class of antibiotics.
- Tell your doctor if you have liver disease, kidney disease, diabetes, bleeding disorders, gallbladder disease, anemia, diarrhea, pancreatitis , malnutrition, or digestive disorders, such as ulcerative colitis .
- Tell your doctor if you are getting vaccinated with a live bacterial vaccine, such as the typhoid vaccine, BCG vaccine, or cholera vaccine. Ceftriaxone may decrease the effectiveness of this vaccine.
- Tell your doctor that you are using ceftriaxone before having surgery or any medical procedure, including dental surgery.
- Tell your doctor if you are taking other medications, including supplements and herbal products, to avoid drug interactions.
- Tell your doctor if you are pregnant, planning a pregnancy, or are breastfeeding.
- Immediately consult a doctor if you experience a drug allergic reaction , serious side effects, or an overdose after using ceftriaxone.
Dosage and Rules for Use of Ceftriaxone
Cefriaxone is given as an injection. Ceftriaxone can be given by IM injection (intramuscular/through muscle), IV injection (intravenous/through a vein), or IV infusion by a doctor or medical staff under the supervision of a doctor.
The dose of ceftriaxone varies for each patient. The doctor will determine the dosage and duration of treatment according to the patient's condition. In children, the dose of ceftriaxone will be determined by the doctor based on the patient's weight (BB).
The following is the distribution of ceftriaxone doses based on the condition being treated:
Condition: Bacterial infection that can be treated with ceftriaxone
- Adults: 1,000–2,000 mg per day. In severe infections, the dose may be increased to 4,000 mg 1–2 times daily. Treatment is given by IM injection, IV injection over 5 minutes, or IV infusion over 30 minutes.
- Children aged < 15 days : 20–50 mg/kg, once a day given by IV infusion for 60 minutes.
- Children 15 days to 12 years: 50–80 mg/kg per day. The maximum dose is 4,000 mg per day.
Condition: Gonorrhea without complications
- Adult: 250–500 mg as a single dose by IM injection.
Condition: Acute otitis media
- Adults and children >12 years, weighing ≥50 kg: 000–2,000 mg as a single dose by IM injection.
- Children aged ≤12 years weighing <50 kg: 50 mg/kg as a single dose by IM injection.
- Adult: 500–1000 mg or 2000 mg for syphilis affecting the brain, once daily, for 10–14 days. Treatment can be given by IM injection, IV injection over 5 minutes, or infusion over 30 minutes.
- Children aged < 15 days: 50 mg/kg per day by IV injection over 60 minutes.
- Children 15 days to 12 years: 75–100 mg/kg per day by IV injection, for 10–14 days. The maximum dose is 4,000 mg/kg per day.
Condition: Lyme disease
- Adult: 000 mg once daily for 14–21 days. Treatment can be given by IM injection, IV injection over 5 minutes, or infusion over 30 minutes.
- Children 15 days to 12 years old weighing <50 kg: 50–80 mg/kg, once daily for 14–21 days. Treatment can be given by infusion for at least 30 minutes.
- Adult: 2,000 mg by 12 hours by IV injection for 7–14 days.
- Children: 100 mg/kg per day, in 1 dose or 2 doses, by IV or IM injection, for 7–14 days.
Condition: Prevention of surgical wound infection
- Adult: 1000–2000 mg, given by IV injection ½ –2 hours before surgery.
- Children < 15 days old: 20–50 mg/kg by IV infusion over 60 minutes.
- Children aged 15 days to 12 years weighing <50 kg : 50–80 mg/kg by IV infusion over 30 minutes.
How to use Ceftriaxone correctly
Ceftriaxone is only available in injectable form. Therefore, this drug should only be given by a doctor or medical officer under the supervision of a doctor. The doctor will determine the method and schedule for administering ceftriaxone according to the patient's condition.
While undergoing treatment with ceftriaxone, it is recommended to drink lots of water so that your kidney health is maintained. If you are taking ceftriaxone on an outpatient basis, follow the control schedule determined by the doctor.
Ceftriaxone Interactions with Other Drugs
Interaction effects that can occur if ceftriaxone is used with other drugs are:
- Increased risk of crystal deposition in the lungs and kidneys which can be fatal if used with fluids containing calcium, such as calcium gluconate
- Increased risk of bruising or bleeding when used with warfarin
- Increased risk of kidney damage when used with aminoglycoside antibiotics
Ceftriaxone Side Effects and Dangers
Some of the side effects that can occur after using ceftriaxone are:
- Swelling, redness, or pain at the injection site
- Nausea or vomiting
- vaginal itching or discharge
- skin rash
- Stomach ache
- Excessive sweating
Check with your doctor if the complaints mentioned above do not subside or get worse. Immediately see a doctor if you experience an allergic drug reaction, or more severe side effects, such as:
- Irregular heartbeat ( arrhythmia )
- Appearance of signs of infection, such as fever, chills, or sweats
- bloody diarrhea
- Shortness of breath or wheezing
- Dark or pink urine
- Pain when urinating
- back pain
- Uncontrolled body movements
- Bruising or bleeding
- Fatigue or limp